Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation

A 32-year-old patient developed an anaphylactic reaction minutes after oral intake of acetaminophen-containing tablets (Doregrippin(R)). Scratch testi ng of the whole preparation was positive in contrast with the negative resu lts obtained with pure acetaminophen. Therefore, scratch tests with the rem aining drug components were performed and showed polyvinylpyrrolidone (PVP) to be the aetiological agent. Furthermore, specific IgE antibodies against PVP were demonstrated using a dot blot technique, thus ruling out a pseudo -allergic reaction. This case underlines the necessity to consider not only the active ingredient, but also additives as the causative agent.