Abrogation of tumor vasculature using gene therapy

Anti-angiogenic gene therapy may be rational approach in the treatment of s olid tumors. The current state of gene therapy with regard to the abrogatio n of tumor vasculature is reviewed in this article and the different admini stration vehicles are noted. Furthermore, this article discusses the influe nce of vascular support cells in the tumor vasculature and choice of pre-cl inical model for anti-angiogenic cancer gene therapy.