Development of small peptides recognizing a monosaccharide by combinatorial chemistry

Citation
N. Sugimoto et al., Development of small peptides recognizing a monosaccharide by combinatorial chemistry, CHEM COMMUN, (23), 2000, pp. 2295-2296
Citations number
18
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
23
Year of publication
2000
Pages
2295 - 2296
Database
ISI
SICI code
1359-7345(2000):23<2295:DOSPRA>2.0.ZU;2-F
Abstract
Small peptides selected from a library of 62000 chemically synthesized pept ides were able to recognize a monosaccharide specifically and efficiently u sing both sandwiching and hydrogen bonding interactions, much like sugar-bi nding proteins (lectins) with the appropriate orientation of amino acid sid e chains.