The Mannich reaction of 4-methylacetophenone with aromatic aldehydes and aromatic amines

In the presence of catalytical amount of concentrated hydrochloric acid, 4- methylacetophenone can react directly with benzaldehyde, 4-methylbenzaldehy de and some aromatic amines in ethanol solution at 26 similar to 32 degrees C to afford 1-(4-methylphenyl)-3-aryl-3-arylamino-1-propanones with 61%simi lar to 96% yield. There are seven new compounds among the 17 substances pre pared. The IR and H-1 NMR spectra and elemental analyses of these Mannich b ases are given and they are consistent with the structures of these compoun ds.