Bm. Imbert-marcille et al., Human herpesvirus 6 infection after autologous or allogeneic stem cell transplantation: A single-center prospective longitudinal study of 92 patients, CLIN INF D, 31(4), 2000, pp. 881-886
To determine the incidence and clinical relevance of active human herpesvir
us 6 (HHV-6) infection, 92 consecutive unselected recipients of autologous
or allogeneic stem cell grafts were investigated in a prospective longitudi
nal study. Active infection was assessed by the presence of viral deoxyribo
nucleic acid (DNA) in 846 peripheral blood mononuclear cell specimens and 1
15 plasma specimens, by means of a specially developed polymerase chain rea
ction designed to avoid detection of latent genome. The incidence of HHV-6
infection observed was 42.5%, irrespective of the type or source of graft,
and infection was significantly associated with partial (P = .002) or total
myelosuppression (P = .01) and fever (P < .000001). Infusion of bone marro
w as the source of graft, reactivation occurring before platelet or neutrop
hil engraftment, and presence of HHV-6 DNA in plasma were identified as ris
k factors for symptomatic HHV-6 infection (P < .002).