Short-course of oral miltefosine for treatment of visceral leishmaniasis

Authors
Sundar, S Makharia, A More, DK Agrawal, G Voss, A Fischer, C Bachmann, P Murray, HW
Citation
S. Sundar et al., Short-course of oral miltefosine for treatment of visceral leishmaniasis, CLIN INF D, 31(4), 2000, pp. 1110-1113
Citations number
11
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
10584838 → ACNP
Volume
31
Issue
4
Year of publication
2000
Pages
1110 - 1113
Database
ISI
SICI code
1058-4838(200010)31:4<1110:SOOMFT>2.0.ZU;2-Q
Abstract
A total of 54 Indian patients with visceral leishmaniasis were treated with oral miltefosine, 50 mg given twice daily, for 14 days (18 patients; group A), 21 days (18; group B), or 28 days (18; group C). Cure was achieved in 89% of group A, 100% of group B, and 100% of group C. Adverse reactions wer e self-limited and primarily mild. The 21-day miltefosine regimen combines high-level efficacy, convenient dosing, and a relatively short duration.