Bone formation into surface phosphonylated polymeric implants

Citation
Jm. Allan et al., Bone formation into surface phosphonylated polymeric implants, CR R BIOMED, 28(3-4), 2000, pp. 377-382
Citations number
23
Categorie Soggetti
Multidisciplinary
Journal title
CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING
ISSN journal
0278940X → ACNP
Volume
28
Issue
3-4
Year of publication
2000
Pages
377 - 382
Database
ISI
SICI code
0278-940X(2000)28:3-4<377:BFISPP>2.0.ZU;2-P
Abstract
Through the use of two animal models, the present study demonstrates the ab ility of phosphonylated surfaces to bind bone. In one model, surface-treate d polypropylene (PP) and polyethylene (PE) were implanted in the medial cor tex of the goat tibia. In the second model, surface-treated poly(ether-ethe r ketone) (PEEK) and carbon fiber-reinforced PEEK (CFR-PEEK) were implanted through both cortices of the goat mandible. Selected rods of all material types were microtextured using crystallization induced microphase separatio n, a method for the formation of continuous, open-cell microporous surfaces in thermoplastic polymers.' Microtextured and smooth rods were phosphonyla ted, and calcium was subsequently introduced to the phosphonylated surface by incubating the samples in a saturated solution of calcium oxide.(2-4) Fo r all substrate materials tested, phosphonylation and calcium posttreatment resulted in an increased propensity for bone binding and apposition, as me asured by push out test. Microtextured PP, PE, and CFR-PEEK surfaces that w ere further phosphonylated and calcium treated resulted in test samples wit h an increased interfacial strength.