Absorbable mesh aids in development of discrete, tissue-engineered constructs

Absorbable mesh was investigated as a potential containment material in whi ch to house discrete, small, tissue-engineered constructs. The mesh was fas hioned into bags of varying shapes and consistent volumes. Cells were culti vated on porous, collagen beads, and the tissue constructs were placed into the bags. The mechanical integrity of the bags and feasibility of the desi gn was tested in vitro. The bags successfully maintained their integrity as the cells developed on the collagen matrices. Furthermore, their porosity allowed access of nutrients and waste products to and from the developing t issue. Having demonstrated feasibility of processing, the next step is to o ptimize the cell culture specifications and materials design.