Control of mitosis by changes in the subcellular location of cyclin-B1-Cdkw and Cdc25C

Authors
Takizawa, CG Morgan, DO
Citation
Cg. Takizawa et Do. Morgan, Control of mitosis by changes in the subcellular location of cyclin-B1-Cdkw and Cdc25C, CURR OP CEL, 12(6), 2000, pp. 658-665
Citations number
57
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
12
Issue
6
Year of publication
2000
Pages
658 - 665
Database
ISI
SICI code
0955-0674(200012)12:6<658:COMBCI>2.0.ZU;2-T
Abstract
Nuclear events of mitosis are initiated when the protein kinase cyclin-B1-C dk1 is translocated into the nucleus during prophase. Recent work has unvei led many of the mechanisms that govern the localization of cyclin-B1-Cdk1 a nd its regulator Cdc25C. Phosphorylation-dependent changes in the rate of n uclear import and export of these proteins help to control the onset of mit osis both in normal cells and in cells delayed before mitosis by DNA damage .