Regulation of vascular endothelial nitric oxide production by fatty acids

The consumption of fish and omega-3 fatty acids has been associated with re duced morbidity and mortality from coronary heart disease. The precise mech anisms by which fatty acids modulate atherosclerotic vascular disease remai n to be defined. Experimental evidence suggests that fatty acids alter the function of the vascular endothelium, a metabolically active tissue that in tegrates signals between the circulation and the vascular wall. This review focuses on the effects of fatty acids on vascular endothelial nitric oxide production. Endothelial-derived nitric oxide regulates several vascular wa ll events that participate in the evolution of vascular disease. Impairment of endothelial nitric oxide production has been demonstrated in a variety of conditions such as smoking, diabetes, and hypertension that are risk fac tors for atherosclerosis. Evidence is reviewed that supports the postulate that both qualitative and quantitative alterations in circulating fatty aci d species modulate vascular endothelial nitric oxide production. Although t he mechanisms by which fatty acids alter vascular nitric oxide production r emain obscure, fatty acid-mediated alterations in endothelial gene expressi on present a promising area for future investigation.