A pharmacokinetic study of JOMO-tech (R) in rats

A pharmacokinetic study of Tc-99m labelled JOMO-tech(R) in rats (after intr avenous administration of a dose of 20 mug/kg body weight) was conducted. J OMO-tech(R) is a heterogeneous extract derived from Nocardia opaca cell wal ls. An excellent fitting of the three-compartmental disposition model was a chieved. The first apparent elimination half-life was very short (t(1/2 alp ha) = 0.0572 +/- 0.01383 h) followed by longer second apparent elimination half-life (t(1/2 beta) = 0.817 +/- 0.1922 h), whereas at late post-treatmen t time the third apparent elimination half-life (t(1/2 gamma) = 21.7 +/- 2. 1 h) proved to be long. The peak concentration in the blood extrapolated to t = 0 yielded 32.3 +/- 7.54 ngeq/ml, this being approximately 2-fold the a mount of that measured in the 5th post-treatment minute (16.84 +/- 1.447 ng eq/ml). It was determined that the main route of excretion was renal. Up to the 48th post-treatment hour, 30.03 +/- 2.788% of the dose was excreted vi a the urine, and only 6.71 +/- 0.973% was excreted in the feces by the 7 ra ts evaluated. The amount of radioactivity detected in selected tissue sampl es (expressed in ngeq JOMO-tech(R)/g wet tissue) decreased in the sequence liver > kidneys > lungs > blood > plasma. In the time period studied, the h ighest amount of the dose was found in the liver, whereas up to the 3rd pos t-treatment day a practically equivalent part of the dose was found in the excreta and in the liver.