A pharmacokinetic study of Tc-99m labelled JOMO-tech(R) in rats (after intr
avenous administration of a dose of 20 mug/kg body weight) was conducted. J
OMO-tech(R) is a heterogeneous extract derived from Nocardia opaca cell wal
ls. An excellent fitting of the three-compartmental disposition model was a
chieved. The first apparent elimination half-life was very short (t(1/2 alp
ha) = 0.0572 +/- 0.01383 h) followed by longer second apparent elimination
half-life (t(1/2 beta) = 0.817 +/- 0.1922 h), whereas at late post-treatmen
t time the third apparent elimination half-life (t(1/2 gamma) = 21.7 +/- 2.
1 h) proved to be long. The peak concentration in the blood extrapolated to
t = 0 yielded 32.3 +/- 7.54 ngeq/ml, this being approximately 2-fold the a
mount of that measured in the 5th post-treatment minute (16.84 +/- 1.447 ng
eq/ml). It was determined that the main route of excretion was renal. Up to
the 48th post-treatment hour, 30.03 +/- 2.788% of the dose was excreted vi
a the urine, and only 6.71 +/- 0.973% was excreted in the feces by the 7 ra
ts evaluated. The amount of radioactivity detected in selected tissue sampl
es (expressed in ngeq JOMO-tech(R)/g wet tissue) decreased in the sequence
liver > kidneys > lungs > blood > plasma. In the time period studied, the h
ighest amount of the dose was found in the liver, whereas up to the 3rd pos
t-treatment day a practically equivalent part of the dose was found in the
excreta and in the liver.