Characterisation with stable isotopes of the presence of a lag phase in the gastric emptying of liquids

Background Gastric emptying of non-nutrient liquids usually lacks the prese nce of an initial delay phase (lag phase), and so it has been considered to be monoexponential with an initial rapid phase followed by a slower emptyi ng phase. However a lag phase in the gastric emptying of liquids can be fou nd if there is a high caloric density in the liquid meal. Aim of the study To characterise with stable isotopes the presence of a lag phase in the gas tric emptying of non-solid meals. Methods Healthy volunteers ingested a low caloric liquid meal (345 KJ/200 mL) (LCLM), a high caloric liquid meal (11 35 KJ/180 mL) (HCLM) or a semisolid meal (1403 KJ/500 mL) (SSM). Test meals were labelled with C-13-acetate. Breath samples were collected for (CO2)-C -13 measurement and data were fitted to a power exponential function. Resul ts Non-solid meals can have different behaviour related to the initial empt ying. The presence of a lag phase in the gastric emptying of liquids was no t masked by the processing of the tracer previous to its detection in breat h. While the LCLM and SSM showed a rapid initial emptying phase (no lag pha se), the HCLM has an initial slow emptying phase. The slower gastric emptyi ng of the HCLM compared to the SSM was related to the presence of a lag pha se in the gastric emptying of the HCLM. Conclusions The C-13-acetate breath test is very accurate to identify and study the lag phase if present of li quid meals.