Heterogeneity of glycoprotein fractions in blood serum of tumor-bearing animals

Authors
Surgova, TM Sidorenko, MV Galich, IP Evtushenko, NV
Citation
Tm. Surgova et al., Heterogeneity of glycoprotein fractions in blood serum of tumor-bearing animals, EXP ONCOL, 22(3), 2000, pp. 148-152
Citations number
20
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
EXPERIMENTAL ONCOLOGY
ISSN journal
02043564 → ACNP
Volume
22
Issue
3
Year of publication
2000
Pages
148 - 152
Database
ISI
SICI code
0204-3564(200009)22:3<148:HOGFIB>2.0.ZU;2-8
Abstract
Glycoprotein fractions (GPF) from blood serum of tumor-bearing animals (B16 melanoma and Guerin carcinoma) were purified by affinity chromatography on Sepharose columns and analyzed. The growth of transplantable tumors was sh own to be accompanied by the changes in structure and properties of GPFs un der study, in particular by the changes in sugar content in the carbohydrat e moieties of GPFs. The content of fucose in serum decreased as far as the tumors were increasing in size.