Access to new cytotoxic bisindole alkaloids by a modified borch reductive amination process

Authors
Lewin, G Schaeffer, C Hocquemiller, R Jacoby, E Leonce, S Pierre, A Atassi, G
Citation
G. Lewin et al., Access to new cytotoxic bisindole alkaloids by a modified borch reductive amination process, HETEROCYCLE, 53(11), 2000, pp. 2353
Citations number
6
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
11
Year of publication
2000
Database
ISI
SICI code
0385-5414(20001101)53:11<2353:ATNCBA>2.0.ZU;2-9
Abstract
A slight modification of the Borch reductive amination method (delayed addi tion of NaBH3CN) was applied to an indole aldehyde compound, analog of the natural alkaloid, goniomitine. This reaction led to a series of new cytotox ic bisindole alkaloids with a 1,2,3,4-tetrahydroquinoline bridge.