Association of the human Y chromosome with high blood pressure in the general population

Genetic variation in the Y chromosome has significant effects on male blood pressure in experimental animals, but the effects in humans are unknown. W e examined the relationship between blood pressure and a polymorphic HindII I restriction site in the nonrecombining region of the Y chromosome in 409 randomly selected men from the general population. Carefully standardized m easures of systolic and diastolic blood pressures were made. The HindIII re striction site was significantly more common (43.2%) in men in the lowest d ecile of the diastolic blood pressure distribution than men in the highest decile (15.9%, P = 0.007). No significant difference in genotype frequency was observed between the lowest and highest deciles for systolic pressure ( 32.4% versus 27.8%, P = 0.66). In the entire group, men with the HindIII re striction site had significantly lower diastolic blood pressures (81.2 mm H g, SD:8,3, versus 83.2 mm Hg, SD:8.7, P = 0.03). No significant differences in systolic blood pressure (130.6 mm Hg, SD:14.7, versus 128.3 mm Hg, SD: 13.6) were observed in relation to genotypes. Our results indicate that gen etic variation in the human Y chromosome is associated with high blood pres sure and contributes significantly to the quantitative variation of male di astolic blood pressure in the general population.