A clinical prototype for active microwave imaging of the breast

Despite its recognized value in detecting and characterizing breast disease , X-ray mammography has important limitations that motivate the quest for a lternatives to augment the diagnostic tools that are currently available to the radiologist. The rationale for pursuing electromagnetic methods is str ong given: the data in the literature, which show that the electromagnetic properties of breast malignancy are significantly different than normal in the high megahertz to low gigahertz spectral range, microwave illumination can effectively penetrate the breast at these frequencies, and the breast i s a small readily accessible tissue volume, making it an ideal site for dep loying advanced near-field imaging concepts that exploit model-based image reconstruction methodology. In this paper, a clinical prototype of a microw ave imaging system, which actively illuminates the breast with a 16-element transceiving monopole antenna array in the 300-1000-MHz range, is reported , Microwave exams have been delivered to five women through a water-coupled interface to the pendant breast with the participant positioned prone on a n examination table, This configuration has been found to be a practical, c omfortable approach to microwave breast imaging, Sessions lasted 10-15 min per breast and included full tomographic data acquisition at seven differen t array heights beginning at the chest wall and moving anteriorly toward th e nipple for seven different frequencies at each array position. This clini cal experience appears to be the first report of active near-field microwav e imaging of the breast and is certainly the first attempt to exploit model -based image reconstructions from in vivo breast data in order to convert t he measured microwave signals into spatial maps of electrical permittivity and conductivity, While clearly preliminary, the results are encouraging an d have supplied some interesting findings. Specifically, it appears that th e average relative permittivity of the breast as a whole correlates with ra diologic breast density categorization and may be considerably higher than previously published values, which have been based on ex vivo tissue specim ens.