Behaviour change and treatment of core groups: its effect on the spread ofHIV/AIDS

Citation
Yh. Hsieh et K. Cooke, Behaviour change and treatment of core groups: its effect on the spread ofHIV/AIDS, IMA J MATH, 17(3), 2000, pp. 213-241
Citations number
35
Categorie Soggetti
Multidisciplinary
Journal title
IMA JOURNAL OF MATHEMATICS APPLIED IN MEDICINE AND BIOLOGY
ISSN journal
02650746 → ACNP
Volume
17
Issue
3
Year of publication
2000
Pages
213 - 241
Database
ISI
SICI code
0265-0746(200009)17:3<213:BCATOC>2.0.ZU;2-I
Abstract
A general model is considered for treatment and behaviour change of the Hum an Immunodeficiency Virus (HIV) infecteds in a highly sexually active core group of female commercial sex workers (CSWs) and a 'bridge population' of young unpartnered males. In this model, the spread of HIV/AIDS in the commu nity is carried out mainly through the sexual interaction between the core group and the bridge population which acts as a bridge for the spread of di sease to the general population. We will consider the effect of treatment o f the infecteds and/or the subsequent behaviour change when targeted toward the core group and the bridge population Analytical results will be given for a strategy which targets treatment and behaviour change at either the c ore group or the bridge population. Numerical examples are also provided to illustrate the biological significance of the treatment/behaviour change a nd its effect on the threshold parameter values. The results show that if t he contact rates and transmission probabilities of the treated individuals are sufficiently reduced, the treatment/behaviour change can eradicate the disease provided that the level of treatment in the infected population is sufficiently high. However, an ill-planned treatment program which fails to meet the required reductions in contact rate or transmission probability c ould have a detrimental effect on the spread of the epidemic.