Aim: To review the evidence on using Guided Tissue Regeneration (GTR) techn
iques and materials in various clinical circumstances. Method: Literature r
eview. Main outcome measures: The success of GTR techniques and materials i
n halting or reversing the destruction of tooth attachment apparatus caused
by progressive periodontal disease. Results: GTR and osseous grafting are
the two techniques with the most clinical and histological documentation of
periodontal regeneration. Conclusions: GTR materials, whether non-resorbab
le or bioabsorbable, give similar clinical results. GTR procedures have bee
n demonstrated to be clinically effective in treating infrabony osseous def
ects, recession defects, preserving alveolar bone in recent extraction site
s and in some types of furcation defects. GTR procedures are technique sens
itive and are adversely affected by poor home oral hygiene care, poor follo
w-up professional maintenance care and smoking.