Smzh. Asna et Ja. Haq, Decrease of antibiotic resistance in Salmonella typhi isolated from patients attending hospitals of Dhaka City over a 3 year period, INT J ANT A, 16(3), 2000, pp. 249-251
Salmonella typhi is an important cause of enteric fever in Bangladesh. Resi
stance to commonly used antibiotics like cotrimoxazole and ampicillin has l
ed to the introduction of third generation cephalosporins and fluoroquinolo
nes for the treatment of enteric fever. Prescription patterns for enteric f
evers and for other infections have been changing and so we looked at the a
ntibiotic resistance of S. typhi isolated from patients in and around Dhaka
City from 1996-1998. The study showed a gradual change in resistance to am
picillin and cotrimoxazole among S. typhi in our area. The rate of resistan
ce to cotrimoxazole, ampicillin and chloramphenicol decreased from 59.6 to
5.6% in S. typhi over a 3 year period. The extensive use of third generatio
n cephalosporins and fluoroquinolones. in place of conventional antibiotics
, has probably influenced the change in resistance pattern in S. typhi. (C)
2000 Elsevier Science B.V. and international Society of Chemotherapy. All
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