Synthesis and antifungal activity of novel bisdithiocarbamate derivatives of carbohydrates against Fusarium oxysporum f. sp lini

Novel carbamic esters possessing a carbohydrate moiety derived from glycero l or D-glucose with two N,N-diethyldithiocarbamoyl groups and a series of b isdithiocarbamic esters having a ketone or an alkyl ester have been synthes ized. The in vitro activity of these new compounds was evaluated against Fu sarium oxysporum f. sp. lini. Some of the compounds [bis[1,3-S-(N,N-diethyl dithiocarbamoyl)]-1,3-dideoxyglycerol) and diethyl N,N'-(1,3-dideoxyglycer- 1,3-diyl)bis(dithiocarbamate)] were more active for inhibiting vegetative m ycelium growth than, respectively, the commercial N,N-diethyldithiocarbamic acid sodium salt and Maneb. The structure activity of these new compounds is discussed.