Suppression of the furylfuramide-induced SOS response by monoterpenoids with a p-menthane skeleton using the Salmonella typhimurium TA1535/pSK1002 umu test

Suppression of the furylfuramide-induced SOS response by 25 kinds monoterpe noids (hydrocarbons, alcohols, ketones, and aldehydes) with a p-menthane sk eleton was studied. Suppression of the SOS-inducing activity by monoterpeno ids was determined in the umu test using Salmonella typhimurium TA1535/pSK1 002. The terpene alcohols, ketones, and aldehydes had potent suppressive ef fects, but the hydrocarbons did not. Especially, (+)-menthol, (+)-pulegone, piperitenone, and cuminaldehyde were shown to have the most potent suppres sive effects, and the ID50 (dose for 50% inhibition) was 0.52 mu mol/mL.