Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France

Authors
Lemee, V Zaharia, I Nevez, G Rabodonirina, M Brasseur, P Ballet, JJ Favennec, L
Citation
V. Lemee et al., Metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France, J ANTIMICRO, 46(5), 2000, pp. 819-821
Citations number
11
Categorie Soggetti
Pharmacology,Microbiology
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
46
Issue
5
Year of publication
2000
Pages
819 - 821
Database
ISI
SICI code
Abstract
The metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France was determined using a neonatal mouse model and compared with the outcome in patients after standard metronidazole the rapy (0.75 g/day for 5 days), All isolates found to be clinically resistant to metronidazole (4/11) exhibited an ID50 > 120 mg/kg in the mouse model. This therefore appears to be a suitable animal model in which to explore dr ug failures in human giardiasis.