Identification and characterization of the antigen presenting cell in rat autoimmune myocarditis: Evidence of bone marrow derivation and non-requirement for MHC class I compatibility with pathogenic T cells

Together, these experiments confirm that activated effector T cells, in ord er to produce myocarditis, require MHC class ii compatible APCs in the hear t, that these APCs are bone marrow derived, and will endogenously take up a nd present local antigens in the target organ after bone marrow reconstitut ion. (C) 2000 Academic Press.