NEW DIALLELIC MARKERS IN THE HLA REGION OF CHROMOSOME-6

Diallelic polymorphisms have been identified in the HLA-H gene and the ZNF192 gene located about 2 megabases centromeric to HLA-H, The three polymorphic sites in HLA-H together with the two hemochromatosis muta tions in this gene give rise to 8 different haplotypes, The three poly morphic sites in ZNF192 give rise to 4 different haplotypes. The haplo types in HLA-H are in complete linkage disequilibrium with the two com mon mutations in that gene, 845A (C282Y) and 187G (H63D), The 845A mut ation is in weak linkage disequilibrium with the ZNF192 polymorphisms and the 187G mutation appears to be in equilibrium with this polymorph ism, The 187G mutation therefore appears to be the older of the two HL A-H mutations.