Selective T-cell deficiency in Turner's syndrome

The case of a 29-year-old Caucasian woman with 45 X0 karyotype, known as Tu rner's syndrome, and a recently diagnosed selective T-cell deficiency is re ported. The main clinical features of the patient were recurrent sinopulmon ary infections and a negative skin test with seven common recall antigens. Laboratory findings included lymphocytopenia, highly elevated CD45RA/CD45R0 ratio, as well as reduced expression of the co-stimulatory molecules CD154 , CD86, CD80 and CD28 on CD4+ cells in combination with disturbed lymphocyt e transformation in vitro. Markedly decreased levels of interleukin (IL)-2R , both on lymphocyte surface as well as the soluble analog, suggest a new f orm of x-linked immunodeficiency associated with Turner's syndrome.