PROCESSING OF ALZHEIMERS AMYLOID PRECURSOR PROTEIN DURING H2O2-INDUCED APOPTOSIS IN HUMAN NEURONAL CELLS

Authors
ZHANG L ZHAO BY YEW DT KUSIAK JW ROTH GS
Citation
L. Zhang et al., PROCESSING OF ALZHEIMERS AMYLOID PRECURSOR PROTEIN DURING H2O2-INDUCED APOPTOSIS IN HUMAN NEURONAL CELLS, Biochemical and biophysical research communications, 235(3), 1997, pp. 845-848
Citations number
29
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
235
Issue
3
Year of publication
1997
Pages
845 - 848
Database
ISI
SICI code
0006-291X(1997)235:3<845:POAAPP>2.0.ZU;2-C
Abstract
The processing of Alzheimer's amyloid precursor protein was studied by Western blotting during H2O2 induced apoptosis in cultures of human n euroblastoma cells. A new 5.5 kDa fragment putatively containing intac t A beta was detected and found to be highly associated with apoptosis . The results suggest a possible vicious cycle involving H2O2, A beta and apoptosis which may contribute to the neuronal death mechanism in Alzheimer's Disease. (C) 1997 Academic Press.