Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder

The insertion/deletion polymorphism of the gene of angiotensin-converting e nzyme (ACE) was investigated in a case-control study including 169 patients with suffering from either bipolar disorder type I or unipolar recurrent m ajor depression (DSM-IV) and 169 healthy controls. No significant associati on was found with bipolar disorder type I or unipolar recurrent depression and the polymorphism of the ACE gene. A previously reported genetic associa tion (Arinami et al., 1996) was not confirmed by the present study.