Protein C deficiency related to valproic acid therapy: A possible association with childhood stroke

Authors
Gruppo, R DeGrauw, A Fogelson, H Glauser, T Balasa, V Gartside, P
Citation
R. Gruppo et al., Protein C deficiency related to valproic acid therapy: A possible association with childhood stroke, J PEDIAT, 137(5), 2000, pp. 714-718
Citations number
12
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
JOURNAL OF PEDIATRICS
ISSN journal
00223476 → ACNP
Volume
137
Issue
5
Year of publication
2000
Pages
714 - 718
Database
ISI
SICI code
0022-3476(200011)137:5<714:PCDRTV>2.0.ZU;2-T
Abstract
We report a case of stroke in a child with acquired protein C deficiency re ceiving valproic acid (VPA). To investigate the possible association of VPA with protein C deficiency, protein C levels were measured in 20 children r eceiving VPA monotherapy and 20 children receiving other anticonvulsants. P rotein C levels were reduced in up to 45% of the VPA-treated subjects.