Metastatic melanoma of the heart

Background: Malignant melanoma has an unpredictable biologic behavior and i s the neoplasm with the greatest propensity for cardiac involvement. Althou gh relatively frequent at autopsy, cardiac metastases are rarely identified antemortem. Methods: We reviewed 2,810 patients with histologically confirmed malignant melanoma, who were diagnosed and followed up by our clinic. Clinical, hist ological, and imaging data are presented. Results: Five cases of metastatic melanoma of the heart were identified out of 314 melanoma patients with visceral involvement. One case of a 53-year- old woman, who died unexpectedly during her first chemotherapy course, is d escribed in detail. Postmortem examination determined the cause of death to be che presence of multiple melanoma metastases in the heart, even though the patient had shown no signs of cardiac involvement. Conclusions: The unpredictable biologic behavior of melanoma may lead to un usual metastatic sites, and, therefore, the heart also should be included i n routine examinations. J. Surg. Oncol. 2000;75:203-207. (C) 2000 Wiley-Lis s, Inc.