Effect of long-acting preparation of isosorbide-5-mononitrate on hemodynamics of pulmonary and systemic circulation in patients with chronic cor pulmonale

Aim. To study effect of course treatment with isosorbide-5-mononitrate (50 mg o.d.) on parameters of systolic and diastolic cardiac function and pulmo nary artery blood pressure in patients with chronic cor pulmonale. Method a nd material. Doppler echocardiography was used for assessment of hemodynami c parameters and estimation of pulmonary artery pressure in 30 patients wit h decompensated chronic cor pulmonale. Results. Treatment with isosorbide-5 -mononitrate was associated with signs of effective unloading of pulmonary circulation, significant lowering of systolic, diastolic and mean pulmonary artery pressure (p<0,05), decreases of cardiac output (p<0,05), right vent ricular end-diastolic dimension (p<0,01), left ventricular end-diastolic (p <0,001) and end-systolic (p<0,01) volumes, augmentation of ejection fractio n (p<0,01) and left ventricular DeltaS% (p<0,05). Significant improvement o f main parameters of right and left ventricular diastolic function was also observed. Conclusion. Long-acting preparation of isosorbide-5-mononitrate can be used in combination therapy of patients with chronic cor pulmonale.