Background: Creutzfeldt-Jakob disease, currently viewed as one of the prion
ic diseases, occurs in by far the majority of cases sporadically, sometimes
in families, and in rare instances as a transmissible disease with every c
onceivable interval of latency.
History and signs: This report of a 45-year-old female concerns a spongifor
m encephalopathy which appeared almost 30 years after penetrating keratopla
sty. The corneal material came from a 63-year-old donor with Creutzfeldt-Ja
kob disease: the keratoplasty was performed at a time when the transmissibi
lity of certain diseases was still unknown.
Conclusion: The risk of transmission of the disease is very low but cannot
be ruled out.