MOLECULAR ANALYSIS OF KATG GENE-MUTATIONS IN STRAINS OF MYCOBACTERIUM-TUBERCULOSIS COMPLEX FROM AFRICA

Authors
HAAS WH SCHILKE K BRAND J AMTHOR B WEYER K FOURIE PB BRETZEL G STICHTGROH V BREMER HJ
Citation
Wh. Haas et al., MOLECULAR ANALYSIS OF KATG GENE-MUTATIONS IN STRAINS OF MYCOBACTERIUM-TUBERCULOSIS COMPLEX FROM AFRICA, Antimicrobial agents and chemotherapy, 41(7), 1997, pp. 1601-1603
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
7
Year of publication
1997
Pages
1601 - 1603
Database
ISI
SICI code
0066-4804(1997)41:7<1601:MAOKGI>2.0.ZU;2-5
Abstract
A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains o f Mycobacterium tuberculosis complex from south, central, and west Afr ica was analyzed by direct sequence analysis and PCR-restriction fragm ent length polymorphism analysis of their catalase-peroxidase (katG) g enes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mut ations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.