IN-VIVO SELECTION OF KLEBSIELLA-PNEUMONIAE STRAINS WITH ENHANCED QUINOLONE RESISTANCE DURING FLUOROQUINOLONE TREATMENT OF URINARY-TRACT INFECTIONS

Authors
DEGUCHI T KAWAMURA T YASUDA M NAKANO M FUKUDA H KATO H KATO N OKANO Y KAWADA Y
Citation
T. Deguchi et al., IN-VIVO SELECTION OF KLEBSIELLA-PNEUMONIAE STRAINS WITH ENHANCED QUINOLONE RESISTANCE DURING FLUOROQUINOLONE TREATMENT OF URINARY-TRACT INFECTIONS, Antimicrobial agents and chemotherapy, 41(7), 1997, pp. 1609-1611
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
7
Year of publication
1997
Pages
1609 - 1611
Database
ISI
SICI code
0066-4804(1997)41:7<1609:ISOKSW>2.0.ZU;2-4
Abstract
We report two cases of failure of fluoroquinolone treatment of urinary tract infections with Klebsiella pneumoniae strains harboring quinolo ne resistance-associated alterations in GyrA and ParC and in vivo sele ction of posttreatment isolates with enhanced fluoroquinolone resistan ce. Active efflux leading to decreased accumulation of a drug enhanced fluoroquinolone resistance in one posttreatment isolate, and an addit ional mutation in parC resulting in an additional amino acid change in ParC was associated with increased resistance in the other.