Bioactive materials to control cell cycle

Many of the present generation biomaterials are still based upon the early concept that implantable materials should be bioinert and therefore designe d to evoke minimal tissue response, if none. However, a growing body of cli nical data demonstrates that the long survivability of these materials is h ampered by high rates of failure, which is primarily attributed to interfac ial instability. It has therefore become understood that this approach is n ot optimal. Modern approaches implicate the use of biomaterials that can ac tively interact with tissues and induce their intrinsic repair and regenera tive potential. This involves control over the cell cycle, the molecular fr amework that controls cell proliferation and differentiation. Class A bioac tive glass-ceramic materials were the first materials shown to endorse thes e properties and, depending upon the rate of resorption and release of ions , can create chemical gradients with specific biological actions over cells and tissues. Optimising this bioactive regenerative capacity of Bioactive glass-ceramics offers great hope for producing biomaterials that can stimul ate growth, repair, and regeneration of any human tissue.