Neutralizing antibodies to interferon (IFN) alpha-2a and IFN beta-1a or IFN beta-1b in MS are not cross-reactive

Authors
Myhr, KM Ross, C Nyland, HI Bendtzen, K Vedeler, CA
Citation
Km. Myhr et al., Neutralizing antibodies to interferon (IFN) alpha-2a and IFN beta-1a or IFN beta-1b in MS are not cross-reactive, NEUROLOGY, 55(10), 2000, pp. 1569-1571
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
55
Issue
10
Year of publication
2000
Pages
1569 - 1571
Database
ISI
SICI code
0028-3878(20001128)55:10<1569:NATI(A>2.0.ZU;2-Y
Abstract
Sera from patients with MS treated with recombinant interferon (rIFN) alpha -2a, rIFN beta -1a, or rIFN beta -1b were analyzed for crossreacting neutr alizing antibodies (NAB). Because cross-reactivity was not found, switching treatment from rIFN beta -1a or rIFN beta -1b to rIFN alpha -2a might prov ide a secondary treatment response in patients with NAB to rIFN beta -1a or rIFN beta -1b. A positive treatment response also might be achieved by swi tching NAB rIFN alpha -2a-positive patients to rIFN beta -1a or rIFN beta - 1b.