MEDICINAL-PLANTS FROM SURINAM - SCREENING OF MEDICINAL-PLANTS FROM SURINAM FOR 5-HT1A LIGANDS - BIOACTIVE ISOQUINOLINE ALKALOIDS FROM THE FRUIT OF ANNONA-MURICATA

Citation
Ja. Hasrat et al., MEDICINAL-PLANTS FROM SURINAM - SCREENING OF MEDICINAL-PLANTS FROM SURINAM FOR 5-HT1A LIGANDS - BIOACTIVE ISOQUINOLINE ALKALOIDS FROM THE FRUIT OF ANNONA-MURICATA, Phytomedicine, 4(2), 1997, pp. 133-140
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
ISSN journal
09447113
Volume
4
Issue
2
Year of publication
1997
Pages
133 - 140
Database
ISI
SICI code
0944-7113(1997)4:2<133:MFS-SO>2.0.ZU;2-O
Abstract
Plants from Suriname (South-America) and several Annona species, inclu ding A. muricata, A. cherimolia, A. montana and A. glabra were screene d for 5-HT1A receptor binding activity by ligand-binding-studies (LBS) . Crude extracts of all Annona species and from Hibiscus bifurcatus, I rlbarchia purpurascens and Scoparia dulcis showed high activity. The i soquinoline alkaloids asimilobine (1), nornuciferine (2), and annonain e (3) were isolated as the active principles from the fruit of Annona muricata. These results may partially explain the use of Hibiscus bifu rcatus and Annona muricata in traditional medicine in Suriname.