NON-ABORTIVE EFFECT OF ADHATODA-VASICA SPISSUM LEAF EXTRACT BY ORAL-ADMINISTRATION IN RATS

Authors
BURGOS R FORCELLEDO M WAGNER H MULLER A HANCKE J WIKMAN G CROXATTO H
Citation
R. Burgos et al., NON-ABORTIVE EFFECT OF ADHATODA-VASICA SPISSUM LEAF EXTRACT BY ORAL-ADMINISTRATION IN RATS, Phytomedicine, 4(2), 1997, pp. 145-149
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences
Journal title
Phytomedicine → ACNP
ISSN journal
09447113
Volume
4
Issue
2
Year of publication
1997
Pages
145 - 149
Database
ISI
SICI code
0944-7113(1997)4:2<145:NEOASL>2.0.ZU;2-1
Abstract
The possible abortive effect of an extract of Adhatoda vasica leaf spi ssum, was studied in rats. The principal alkaloid detected in the extr act was vasicine (0.85 +/- 0.03%). The extract (325 mg/kg/day) was adm inistered with a gastric cannula to a group of 5 pregnant females betw een day 1 and 9 of pregnancy. In another experiment 9 pregnant females received in the water 0.25 and 2.5% of Adhatoda vasica between day 1 and 9 of pregnancy. It was concluded that the administration of Adhato da vasica did not produce abortion in any of the treated groups.