MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats

The present study investigated the effect of postischaemic infusion of an i rreversible monoamine oxidase B (MAO-B) inhibitor, I-deprenyl, an equipoten t dose of a reversible MAO-B inhibitor, lazabemide, or 0.9% NaCl on infarct volumes following focal cerebral ischaemia in rats. The drug doses (0.3 mg /kg) were selected to induce selective MAO-B inhibition (45-55%), but not M AO-A inhibition. The infarct volumes in the cortex or in the striatum did n ot differ between the experimental groups 72 hr after transient occlusion o f the middle cerebral artery, which suggests that during ischaemia/reperfus ion, suppressed oxidative stress by partial MAO-B inhibition or MAO-B indep endent mechanisms such as induction of trophic factors, does not protect ag ainst ischaemia/reperfusion damage.