A respiratory gating technique was developed to allow computed tomography-g
uided needle biopsy of small pulmonary nodules. Twenty-three pulmonary nodu
les less than 15 mm in diameter underwent biopsy with the use of this techn
ique. There were 14 true-positive, eight true-negative, and one false-negat
ive result (diagnostic accuracy, 96%). The diagnostic accuracy for small no
dules without this technique in a historical control was 69% (P < .05).