Effectiveness of continuous positive airway pressure (CPAP) as a treat
ment for obstructive sleep apnea can be limited by poor compliance, bu
t little is known about how to improve compliance. We performed a rand
omized, controlled clinical trial among 33 subjects of two interventio
ns to improve compliance. One group of subjects received weekly phone
calls to uncover any problems and encourage use, another received writ
ten information about sleep apnea and the importance of regular CPAP u
se, and a third served as control subjects. We found that intervention
improved CPAP compliance (p = 0.059) and that the effect was particul
arly strong when intervention occurred during the first month of CPAP
treatment (p = 0.004). Although the sample size did not allow definiti
ve investigation of other explanatory variables, subjects with lower l
evels of education or those with relatives who used CPAP may have bene
fited from intervention more than other subjects. We conclude that sim
ple, inexpensive efforts to improve compliance with CPAP can be effect
ive, especially when applied at the start of CPAP treatment, but optim
al intervention may vary with certain patient characteristics.