CLEAVAGE AND REACTIONS OF SOME NH-BOC PROTECTED 1-AMINOPYRROLES - A NEW ONE-POT ROUTE TO PYRROLO[1,2-B][1,2,4]TRIAZINES TOGETHER WITH SPECTROSCOPIC AND X-RAY STUDIES

1-NH-BOC protected 1,2-diaminopyrroles have been converted by one-pot cleavage of the protecting group and subsequent reaction of the compou nds obtained with 1,2-dicarbonyl compounds into highly substituted pyr rolo[1,2-b][1,2,4]triazines. Structural assignments to the regioisomer s arising from the reaction with phenylglyoxal have been made on the-b asis of NMR spectral evidence. An X-ray crystal structure analysis of 6-ethoxycarbonyl-7-methyl-3-phenyl-5-piperidin-1- ylcarbonylpyrrolo[1, 2-b]-[1,2,4]triazine has been carried out in order to confirm unambigu ously the structure assignment,