PHOSPHOLIPASE-A(2)-MEDIATED STEREOSELECTIVE SYNTHESIS OF (R)-1-O-ALKYLGLYCERO-3-PHOSPHATE AND ALKYL-ACYL ANALOGS - APPLICATION FOR SYNTHESIS OF RADIOLABELED BIOSYNTHETIC PRECURSORS OF CELL-SURFACE GLYCOCONJUGATES OF LEISHMANIA-DONOVANI

Stereoselective syntheses of (R)-1-O-alkylglycero-3-phosphate and alky l-acyl analogues have been achieved using glycerol as starting materia l by an efficient application of Phospholipase-A(2) enzyme from Naja m ocambique mocambique. This synthetic strategy allows a high yielding p reparation of radiolabelled [C-14] and chirally pure biosynthetic prec ursors of GIPLs and LPG cell surface molecules of promastigote and ama stigote forms of the protozoan parasite Leishmania donovani.