Does post-angiographic hemodialysis reduce the risk of contrast-medium nephropathy?

Objective: Several strategies have been employed to reduce the incidence of nephrotoxicity in connection with the administration of urographic contras t media. We present the results of a randomized study to explore the effect of a single hemodialysis treatment immediately after an angiographic exami nation. Material and methods: The patients studied had moderately reduced r enal function. Seventeen of the 32 patients had diabetic nephropathy and 15 had other renal diseases. They were randomly selected to undergo either he modialysis or standard treatment following the angiographic examination. Th e glomerular filtration rate (GFR) was determined the day before and I week after administration of the contrast medium. All patients were hydrated an d received oral calcium-channel blocking treatment before angiography. Resu lts: Hemodialysis lowered the level of contrast medium in plasma by approxi mately 80%. In spite of this no significant difference in renal iohexol cle arance was noted between groups treated and not treated with hemodialysis. Conclusions: The risk of a marked and sustained reduction in renal function after administration of an iodine contrast medium is low with modern angio graphic techniques. Hemodialysis reduces levels of contrast media in plasma but does not reduce the incidence of contrast-medium induced nephrotoxicit y in the GFR range from 10 to 25 ml/min.