Synthetic applications of the thermal rearrangement of ozonides: First enantiospecific synthesis of marine metabolite Luffarin W

The ozonides on quaternary carbons undergo thermal rearrangement to yield a mixture of formates and alkenes. This reaction constitutes an alternative procedure to the unusual Baeyer-Villiger rearrangement of aliphatic aldehyd es. The first enantiospecific synthesis of the marine metabolite Luffarin W from (-)-sclareol has been carried out, based on this methodology.