M. Jesberger et al., Soluble versus insoluble polymers as supports for the preparation of new glycosteroids - a practicability study, SYNLETT, (9), 2000, pp. 1289-1293
Two polymeric supports along with two different linkers for attachment to O
-4 of carbohydrate-derived glycals were evaluated for the solid phase synth
esis of new glycosteroids 9 and 16. From these studies it can be concluded
that soluble MPEG-ethers are less well suited polymeric supports for automa
ted synthesis of glycoconjugates. Furthermore, it was found that glycosylat
ion proceeds with much higher selectivity with polymer-bound glycals 3a and
12 compared to the solution variant.