A HIGH-FREQUENCY OF INDUCTION OF CHROMOSOME-ABERRATIONS IN THE BONE-MARROW CELLS OF LEC STRAIN RATS BY X-IRRADIATION

Authors
OKUI T HAYASHI M ENDOH D SATO F KASAI N WATANABE T NAMIOKA S
Citation
T. Okui et al., A HIGH-FREQUENCY OF INDUCTION OF CHROMOSOME-ABERRATIONS IN THE BONE-MARROW CELLS OF LEC STRAIN RATS BY X-IRRADIATION, Mutation research. Mutation research letters, 324(4), 1994, pp. 165-169
Citations number
22
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
Mutation research. Mutation research letters → ACNP
ISSN journal
01657992
Volume
324
Issue
4
Year of publication
1994
Pages
165 - 169
Database
ISI
SICI code
0165-7992(1994)324:4<165:AHOIOC>2.0.ZU;2-7
Abstract
LEC strain rats, which have been known to develop hereditarily spontan eous fulminant hepatitis 4 to 5 months after birth, are highly sensiti ve to whole-body X-irradiation when compared to WKAH strain rats. The present results showed that the frequencies of all types of chromosome aberrations induced by X-irradiation in the bone marrow cells of LEC rats were approximately 2- to 3-fold higher than those of WKAH rats, t hough no significant difference was observed in the frequency of spont aneous chromosome aberrations between LEC and WKAH rats.