Enantioselective protonation of organolithiums having the tetrahydroisoquinoline skeleton

Authors
Burton, AJ Graham, JP Simpkins, NS
Citation
Aj. Burton et al., Enantioselective protonation of organolithiums having the tetrahydroisoquinoline skeleton, SYNLETT, (11), 2000, pp. 1640-1642
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
11
Year of publication
2000
Pages
1640 - 1642
Database
ISI
SICI code
0936-5214(200011):11<1640:EPOOHT>2.0.ZU;2-4
Abstract
The enantioselective protonation of a series of organolithiums derived from 1-substituted tetrahydroisoquinolines, using the readily available chiral amine 6, proceeds in up to 86% ee and enables a novel asymmetric synthesis of salsolidine.