Facile synthesis of building blocks for C-glycosidic neoglycoconjugates

Highly functionalized C-glycosidic neoglycoconjugate building blocks can be synthesized via an intramolecular ring closing olefin metathesis reaction (RCM). The products can be formed alpha- and beta -selectively while starli ng from their allylated congeners. Due to the intramolecular approach, the RCM is cis-selective leading to cyclized products in high yields. Furthermo re, attachment to polymeric resins may allow solid phase synthesis.