Facile syntheses of fluorine-containing pyrazolo[4,3-h]quinolines and 1H-1,4-diazepino[6,5-h]quinolines

Authors
Okada, E Tsukushi, N Shimomura, N
Citation
E. Okada et al., Facile syntheses of fluorine-containing pyrazolo[4,3-h]quinolines and 1H-1,4-diazepino[6,5-h]quinolines, SYNTHESIS-S, (13), 2000, pp. 1822-1824
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
13
Year of publication
2000
Pages
1822 - 1824
Database
ISI
SICI code
0039-7881(200011):13<1822:FSOFPA>2.0.ZU;2-H
Abstract
N,N-Dimethyl-5,7-bis(trifluoroacetyl)-8-quinolylamine underwent an aromatic nucleophilic N-N exchange reaction with hydrazines followed by cycloconden sation to afford the corresponding fluorine-containing 1H- and 2H-pyrazolo[ 4,3-h]quinolines in excellent yields. This reaction could be extended to th e synthesis of 1H-1,4-diazepino[6,5-h]quinolines using 1,2-ethylenediamine and 1,2-phenylenediamines.