Fd. Boyer et Ph. Ducrot, Synthesis of agarofuran antifeedants, part II: Stereoselective construction of the tetrahydrofuran ring, SYNTHESIS-S, (13), 2000, pp. 1868-1877
This paper describes how to manage the last steps of the synthetic scheme o
f agarofurans synthesis according to the configurations obtained at C-4a an
d C-6 during the functionalization of hexahydronaphthalenones derived from
a Wieland-Misher ketone in order to obtain either cis- or trans-nor-agarofu
rans. Synthesis of nor-agarofurans 20, 24 and 29 are described.